學程成員

國立臺灣大學毒理學研究所博士 Ph.D.Graduate Institute of Toxicology, National Taiwan University

行政院衛生署立桃園醫院院長                      
行政院衛生署立桃園醫院副院長                   
行政院衛生署立桃園醫院新屋分院院長              
行政院衛生署立桃園醫院醫務秘書                
衛生福利部桃園醫院顧問醫師                     
衛生福利部桃園醫院內科主治醫師                  
台大醫院兼任主治醫師                           
國立中興大學兼任教授                            
中國醫藥學院中醫系兼任教授                     
衛生福利部桃園醫院中藥臨床試驗中心負責人                
中原大學醫工系兼任教授                         
中原大學化學系兼任教授                         
中原大學生物科技系兼任教授                     
元智大學生物資訊系兼任教授                             
台北醫學大學內科學系兼任教授
中西結合醫學會理事       
 

The citation of Feng-Ming Ho’s publications were over 3250 times.
 

老化醫學Aging

老化醫學Aging

1. Therapeutic effect of quercetin polymeric nanoparticles on ischemia/reperfusion-induced acute kidney injury in mice

Huang KT , Wu CT , Chang Y , Ho FM , Chiang CK , Liu SH
Biochem Biophys Res Commun  2022 Jun 11:608:122-127

2. Dual specificity phosphatase DUSP6 promotes endothelial inflammation through inducible expression of ICAM-1.

Hsu SF, Lee YB, Lee YC, Chung AL, Apaya MK, Shyur LF, Cheng CF, Ho FM, Meng TC.
FEBS J. 2018 May;285(9):1593-1610.

3. Berberine impairs embryonic development in vitro and in vivo through oxidative stress-mediated apoptotic processes.

Huang CH, Huang ZW, *Ho FM, Chan WH.
Environ Toxicol. 2018 Mar;33(3):280-294.

4. Vitis thunbergii var. taiwaniana Leaf Extract Reduces Blood Glucose Levels in Mice with Streptozotocin-induced Diabetes
   Wan Leung, Ho FM, Wen-Pin Li, Yu-Chih Liang
   International Journal of Pharmacology.2017;13 (5): 457-464.
5. Risks of acute coronary syndrome in patients with osteoarthritis: a nationwide population-based cohort study.

Chung WS, Lin HH, Ho FM, Lai CL, Chao CL.
Clin Rheumatol. 35(11):2807-2813, 2016 Nov.

6. The Protective Role of Autophagy in Matrix Metalloproteinase-Mediated Cell Transmigration and Cell Death in High-Glucose-Treated Endothelial Cells.

Chao CL, Chuang CP, Cheng YF, Lee KR, Chang Y, Cheng SP, Chan WK, Ho FM.
Inflammation. 39(2):830-8, 2016 Apr.

7. Brain Metabolism of Less-Educated Patients with Alzheimer Dementia Studied by Positron Emission Tomography.

Huang YC, Yen PS, Wu ST, Chen JT, Hung GU, Kao CH, Chen TY, Ho FM.
Medicine (Baltimore). 94(30):e1252, 2015 July.

8. BMI and all-cause mortality among middle-aged and older adults in Taiwan: a population-based cohort study.

Chung WS, Ho FM, Cheng NC, Lee MC, Yeh CJ.
Public Health Nutr. 18(10):1839-46, 2015 July.

9. Increased risk of erectile dysfunction among patients with sleep disorders: a nationwide population-based cohort study.

Lin HH, Ho FM, Chen YF, Tseng CM, Ho CC, Chung WS.
IInt J Clin Pract. 69(8):846-52, 2015 Feb.

10. Synergistic impact of nicotine and shear stress induces cytoskeleton collapse and apoptosis in endothelial cells.

Lee YH, Chen RS, Chang NC, Lee KR, Huang CT, Huang YC, Ho FM*.
Ann Biomed Eng. 43(9):2220-30, 2015 Jan.

11. Metabolities of Scutellariae Raldix inhibited the injury of endothelial cells in Hypoxia Device.

Chao CL, Lin PS, Chang NC, Hou YC, Lee PD, Chang NC, Huang YC, Ho FM*
J Med Biol Eng. 35(4): 492-499, 2015 Aug.

12. Increased stroke risk among adult asthmatic patients.

Chung WS, Lin CL, Chen YF, Ho FM, Hsu WH, Kao CH.
Eur J Clin Invest. 44(11):1025-33, 2014 Nov.

13. N-Hydroxycinnamide derivatives of osthole inhibit cell migration and invasion by suppressing Smad2 and Akt pathways in human colorectal adenocarcinoma cells.

Liu LY; Huang WJ; Ho FM; Lin RJ; Lin SY; Suk FM; Liang YC.
Chemico-Biological Interactions. 217:1-8, 2014 Jun.

14. Asthma increases pulmonary thromboembolism risk: a nationwide population cohort study.

Chung WS; Lin CL; Ho FM; Li RY; Sung FC; Kao CH; Yeh JJ.
European Respiratory Journal. 43(3):801-7, 2014 Mar.

15. Possible cancer formation mechanisms--view at the cellular level.

Kuo TC, Ho FM.
Asian Pac J Cancer Prev. 15(17):7487-8, 2014.

16. Hemocompatible control of sulfobetaine-grafted polypropylene fibrous membranes in human whole blood via plasma-induced surface zwitterionization.

Chen SH; Chang Y; Lee KR; Wei TC; Higuchi A; Ho FM; Tsou CC; Ho HT; Lai JY.
Langmuir. 28(51):17733-42, 2012 Dec.

17. Severe hypercalcemia in nonobstructive pyelonephritis with acute renal failure: hit or miss?.

Tsao YT; Lee SW; Hsu JC; Ho FM; Wang WJ.
American Journal of Emergency Medicine. 30(8):1665.e5-7, 2012 Oct.

18. Surviving a crisis of HIV-associated immune reconstitution syndrome.

Tsao YT; Lee SW; Hsu JC; Ho FM; Wang WJ.
American Journal of Emergency Medicine. 30(8):1661.e5-7, 2012 Oct.

19. Inhibition of lipopolysaccharide-induced inducible nitric oxide synthase expression by endoplasmic reticulum stress.

Ho HJ; Huang DY; Ho FM; Lee LT; Lin WW.
Cellular Signalling. 24(11):2166-78, 2012 Nov.

20. PKC-dependent human monocyte adhesion requires AMPK and Syk activation.

Chang MY; Huang DY; Ho FM; Huang KC; Lin WW.
PLoS ONE [Electronic Resource]. 7(7):e40999, 2012.

21. Anti-atherosclerotic action of Ger-Gen-Chyn-Lian-Tang and AMPK-dependent lipid lowering effect in hepatocytes.

Ho FM; Liao YH; Yang AJ; Lee Chao PD; Hou YC; Huang CT; Lin SR; Lee KR; Huang KC; Lin WW.
Journal of Ethnopharmacology. 142(1):175-87, 2012 Jun.

22. Characterization of Staphylococcus lugdunensis endocarditis in patients with cardiac implantable electronic devices. [Review]

Tsao YT; Wang WJ; Lee SW; Hsu JC; Ho FM; Chen WL.
International Journal of Infectious Diseases. 16(6):e464-7, 2012 Jun.

23. Nitrite-mediated S-nitrosylation of caspase-3 prevents hypoxia-induced endothelial barrier dysfunction.

Lai YC; Pan KT; Chang GF; Hsu CH; Khoo KH; Hung CH; Jiang YJ; Ho FM; Meng TC.
Circulation Research. 109(12):1375-86, 2011 Dec.

24. To accomplish preliminary Qigong simulation state by acupuncture.

Ho FM; Ding HY; Chyau CC; Kuo HY; Yen MT; Kuo TC.
Zhong Xi Yi Jie He Xue Bao/Journal of Chinese Integrative Medicine. 9(10):1094-100, 2011 Oct.

25. Grape seed extract ameliorates tumor necrosis factor-alpha-induced inflammatory status of human umbilical vein endothelial cells.

Chao CL; Chang NC; Weng CS; Lee KR; Kao ST; Hsu JC; Ho FM*.
European Journal of Nutrition. 50(6):401-9, 2011 Sep.

26. Celecoxib induces heme oxygenase-1 expression in macrophages and vascular smooth muscle cells via ROS-dependent signaling pathway.

Wang JS; Ho FM; Kang HC; Lin WW; Huang KC.
Naunyn-Schmiedebergs Archives of Pharmacology. 383(2):159-68, 2011 Feb.

27. Oxidative stress initiates DNA damager MNNG-induced poly(ADP-ribose)polymerase-1-dependent parthanatos cell death.

Chiu LY; Ho FM; Shiah SG; Chang Y; Lin WW.
Biochemical Pharmacology. 81(3):459-70, 2011 Feb.

28. Naringenin more effectively inhibits inducible nitric oxide synthase and cyclooxygenase-2 expression in macrophages than in microglia.

Chao CL; Weng CS; Chang NC; Lin JS; Kao ST; Ho FM*.
Nutrition Research. 30(12):858-64, 2010 Dec.

29. Carbon monoxide induces cyclooxygenase-2 expression through MAPKs and PKG in phagocytes.

Lin LC; Ho FM; Yen SJ; Wu PY; Hung LF; Huang WJ; Liang YC.
International Immunopharmacology. 10(12):1520-5, 2010 Dec.

30. AICAR induces cyclooxygenase-2 expression through AMP-activated protein kinase-transforming growth factor-beta-activated kinase 1-p38 mitogen-activated protein kinase signaling pathway.

Chang MY; Ho FM; Wang JS; Kang HC; Chang Y; Ye ZX; Lin WW.
Biochemical Pharmacology. 80(8):1210-20, 2010 Oct.

31. The length ratios between fetal limb bones and nasal bone in the general population.

Yang FY; Chiu WH; Liu SH; Ho FM.
European Journal of Obstetrics, Gynecology, & Reproductive Biology.  148(1):99-100, 2010 Jan.

32. Functional changes in arteries induced by pulsed high-intensity focused ultrasound.

Yang FY; Chiu WH; Liu SH; Lin GL; Ho FM.
IEEE Transactions on Ultrasonics Ferroelectrics & Frequency Control. 56(12):2643-9, 2009 Dec.

33. Effect of ultrasound contrast agent dose on the duration of focused-ultrasound-induced blood-brain barrier disruption.

Yang FY; Liu SH; Ho FM; Chang CH.
Journal of the Acoustical Society of America. 126(6):3344-9, 2009 Dec.

34. Titanium implants alter endothelial function and vasoconstriction via a protein kinase C-regulated pathway.

Yang RS; Tzeng HP; Ho FM; Chuang CC; Chen BL; Huang CF; Chen YW; Chen RM; Liu SH.
Acta Biomaterialia. 5(8):3258-64, 2009 Oct.

35. TR4 nuclear receptor functions as a fatty acid sensor to modulate CD36 expression and foam cell formation.

Xie S; Lee YF; Kim E; Chen LM; Ni J; Fang LY; Liu S; Lin SJ; Abe J; Berk B; Ho FM; Chang C.
Proceedings of the National Academy of Sciences of the United States of America.  106(32):13353-8, 2009 Aug.

36. The antioxidant effects of quercetin metabolites on the prevention of high glucose-induced apoptosis of human umbilical vein endothelial cells.

Chao CL; Hou YC; Chao PD; Weng CS; Ho FM*.
British Journal of Nutrition. 101(8):1165-70, 2009 Apr.

37. Liposome encapsulation reduces cantharidin toxicity.

Chang CC; Liu DZ; Lin SY; Liang HJ; Hou WC; Huang WJ; Chang CH; Ho FM; Liang YC.
Food & Chemical Toxicology. 46(9):3116-21, 2008 Sep.

38. Inhibition of NADPH oxidase-related oxidative stress-triggered signaling by honokiol suppresses high glucose-induced human endothelial cell apoptosis.

Sheu ML; Chiang CK; Tsai KS; Ho FM; Weng TI; Wu HY; Liu SH.
Free Radical Biology & Medicine. 44(12):2043-50, 2008 Jun.

39. Inhibition of lipopolysaccharide-induced inducible nitric oxide synthase and cyclooxygenase-2 gene expression by 5-aminoimidazole-4-carboxamide riboside is independent of AMP-activated protein kinase.

Kuo CL; Ho FM; Chang MY; Prakash E; Lin WW.
Journal of Cellular Biochemistry. 103(3):931-40, 2008 Feb.

40. Genome-wide scan for quantitative ACE activity in Taiwan young-onset hypertension study.

Wang RY; Chung CM; Fann CS; Yang HC; Chen JW; Jong YS; Jou YS; Lo HM; Ho FM; Kang CS; Chen CC; Chang HC; Shyue SK; Pan WH.
Human Heredity. 65(2):85-90, 2008.

41. Hyperglycemia enhances adipogenic induction of lipid accumulation: involvement of extracellular signal-regulated protein kinase 1/2, phosphoinositide 3-kinase/Akt, and peroxisome proliferator-activated receptor gamma signaling.

Chuang CC; Yang RS; Tsai KS; Ho FM; Liu SH.
Endocrinology. 148(9):4267-75, 2007 Sep.

42. The anti-inflammatory actions of LCY-2-CHO, a carbazole analogue, in vascular smooth muscle cells.

Ho FM; Kang HC; Lee ST; Chao Y; Chen YC; Huang LJ; Lin WW.
Biochemical Pharmacology. 74(2):298-308, 2007 Jul.

43. Switch activation of PI-PLC downstream signals in activated macrophages with wortmannin.

Liu DZ; Liang HJ; Chen CH; Lin SY; Zhong WB; Ho FM; Hou WC; Lo JL; Ho YS; Lin PJ; Hung LF; Liang YC.
Biochimica et Biophysica Acta. 1773(6):869-79, 2007 Jun.

44. Opposite effects of high glucose on MMP-2 and TIMP-2 in human endothelial cells.

Ho FM*; Liu SH; Lin WW; Liau CS.
Journal of Cellular Biochemistry. 101(2):442-50, 2007 May.

45. Signaling pathways of LIGHT induced macrophage migration and vascular smooth muscle cell proliferation.

Wei CY; Chou YH; Ho FM; Hsieh SL; Lin WW.
Journal of Cellular Physiology. 209(3):735-43, 2006 Dec.

46. High glucose-induced apoptosis in human vascular endothelial cells is mediated through NF-kappaB and c-Jun NH2-terminal kinase pathway and prevented by PI3K/Akt/eNOS pathway.

Ho FM*; Lin WW; Chen BC; Chao CM; Yang CR; Lin LY; Lai CC; Liu SH; Liau CS.
Cellular Signalling. 18(3):391-9, 2006 Mar.

47. Inhibition of iNOS gene expression by quercetin is mediated by the inhibition of IkappaB kinase, nuclear factor-kappa B and STAT1, and depends on heme oxygenase-1 induction in mouse BV-2 microglia.

Chen JC; Ho FM; Pei-Dawn Lee Chao; Chen CP; Jeng KC; Hsu HB; Lee ST; Wen Tung Wu; Lin WW.
European Journal of Pharmacology. 521(1-3):9-20, 2005 Oct.

48. Oregonin inhibits lipopolysaccharide-induced iNOS gene transcription and upregulates HO-1 expression in macrophages and microglia.

Lee CJ; Lee SS; Chen SC; Ho FM; Lin WW.
British Journal of Pharmacology. 146(3):378-88, 2005 Oct.

49. Cell apoptosis induced by a synthetic carbazole compound LCY-2-CHO is mediated through activation of caspase and mitochondrial pathways.

Hsu MJ; Chao Y; Chang YH; Ho FM; Huang LJ; Huang YL; Luh TY; Chen CP; Lin WW.
Biochemical Pharmacology. 70(1):102-12, 2005 Jul.

50. High glucose induces human endothelial cell apoptosis through a phosphoinositide 3-kinase-regulated cyclooxygenase-2 pathway.

Sheu ML; Ho FM; Yang RS; Chao KF; Lin WW; Lin-Shiau SY; Liu SH.
Arteriosclerosis, Thrombosis & Vascular Biology. 25(3):539-45, 2005 Mar.

51. Decoy receptor 3 increases monocyte adhesion to endothelial cells via NF-kappa B-dependent up-regulation of intercellular adhesion molecule-1, VCAM-1, and IL-8 expression.

Yang CR; Hsieh SL; Ho FM; Lin WW.
Journal of Immunology. 174(3):1647-56, 2005 Feb.

52. The possible role of heat shock factor-1 in the negative regulation of heme oxygenase-1.

Chou YH; Ho FM; Liu DZ; Lin SY; Tsai LH; Chen CH; Ho YS; Hung LF; Liang YC.
International Journal of Biochemistry & Cell Biology. 37(3):604-15, 2005 Mar.

53. Up-regulation of the association between heat shock protein 90 and endothelial nitric oxide synthase prevents high glucose-induced apoptosis in human endothelial cells.

Lin LY; Lin CY; Ho FM; Liau CS.
Journal of Cellular Biochemistry. 94(1):194-201, 2005 Jan.

54. Activation of phosphoinositide 3-kinase in response to high glucose leads to regulation of reactive oxygen species-related nuclear factor-kappaB activation and cyclooxygenase-2 expression in mesangial cells.

Sheu ML; Ho FM; Chao KF; Kuo ML; Liu SH.
Molecular Pharmacology. 66(1):187-96, 2004 Jul.

55. The soreness and numbness effect of acupuncture on skin blood flow.

Kuo TC; Lin CW; Ho FM.
American Journal of Chinese Medicine. 32(1):117-29, 2004.

56. Proteasome inhibitors up-regulate haem oxygenase-1 gene expression: requirement of p38 MAPK (mitogen-activated protein kinase) activation but not of NF-kappaB (nuclear factor kappaB) inhibition.

Wu WT; Chi KH; Ho FM; Tsao WC; Lin WW.
Biochemical Journal. 379(Pt 3):587-93, 2004 May.

57. The anti-inflammatory carbazole, LCY-2-CHO, inhibits lipopolysaccharide-induced inflammatory mediator expression through inhibition of the p38 mitogen-activated protein kinase signaling pathway in macrophages.

Ho FM; Lai CC; Huang LJ; Kuo TC; Chao CM; Lin WW.
British Journal of Pharmacology. 141(6):1037-47, 2004 Mar.

58. Thiol antioxidant and thiol-reducing agents attenuate 15-deoxy-delta 12,14-prostaglandin J2-induced heme oxygenase-1 expression.

Liu JD; Tsai SH; Lin SY; Ho YS; Hung LF; Pan S; Ho FM; Lin CM; Liang YC.
Life Sciences. 74(19):2451-63, 2004 Mar.

59. Soluble decoy receptor 3 induces angiogenesis by neutralization of TL1A, a cytokine belonging to tumor necrosis factor superfamily and exhibiting angiostatic action.

Yang CR; Hsieh SL; Teng CM; Ho FM; Su WL; Lin WW.
Cancer Research. 64(3):1122-9, 2004 Feb.

60. Signal transduction for inhibition of inducible nitric oxide synthase and cyclooxygenase-2 induction by capsaicin and related analogs in macrophages.

Chen CW; Lee ST; Wu WT; Fu WM; Ho FM; Lin WW.
British Journal of Pharmacology. 140(6):1077-87, 2003 Nov.

61. beta-Lapachone reduces endotoxin-induced macrophage activation and lung edema and mortality.

Tzeng HP; Ho FM; Chao KF; Kuo ML; Lin-Shiau SY; Liu SH.
American Journal of Respiratory & Critical Care Medicine. 168(1):85-91, 2003 Jul 1.

62. Inhibition of interleukin-1beta -induced NF-kappa B activation by calcium/calmodulin-dependent protein kinase kinase occurs through Akt activation associated with interleukin-1 receptor-associated kinase phosphorylation and uncoupling of MyD88.

Chen BC; Wu WT; Ho FM; Lin WW.
Journal of Biological Chemistry. 277(27):24169-79, 2002 Jul 5.

63. Arsenite stimulates cyclooxygenase-2 expression through activating IkappaB kinase and nuclear factor kappaB in primary and ECV304 endothelial cells.

Tsai SH; Liang YC; Chen L; Ho FM; Hsieh MS; Lin JK.
Journal of Cellular Biochemistry. 84(4):750-8, 2002.

64. Cyclooxygenase-2 inducing Mcl-1-dependent survival mechanism in human lung adenocarcinoma CL1.0 cells. Involvement of phosphatidylinositol 3-kinase/Akt pathway.

Lin MT; Lee RC; Yang PC; Ho FM; Kuo ML.
Journal of Biological Chemistry. 276(52):48997-9002, 2001 Dec 28.

65. High glucose-induced apoptosis in human endothelial cells is mediated by sequential activations of c-Jun NH(2)-terminal kinase and caspase-3.

Ho FM; Liu SH; Liau CS; Huang PJ; Lin-Shiau SY.
Circulation. 101(22):2618-24, 2000 Jun 6.

66. Nitric oxide prevents apoptosis of human endothelial cells from high glucose exposure during early stage.

Ho FM; Liu SH; Liau CS; Huang PJ; Shiah SG; Lin-Shiau SY.
Journal of Cellular Biochemistry. 75(2):258-63, 1999 Nov 1.

67. Effect of acupuncture at nei-kuan on left ventricular function in patients with coronary artery disease.

Ho FM; Huang PJ; Lo HM; Lee FK; Chern TH; Chiu TW; Liau CS.
American Journal of Chinese Medicine. 27(2):149-56, 1999.

68. Unruptured congenital aneurysm of the sinus of Valsalva presenting with pulmonary stenosis.

Liau CS; Chu IT; Ho FM.
Catheterization & Cardiovascular Interventions. 46(2):210-3, 1999 Feb.

69. Treatment of iatrogenic femoral artery pseudoaneurysm with percutaneous thrombin injection.

Liau CS; Ho FM; Chen MF; Lee YT.
Journal of Vascular Surgery. 26(1):18-23, 1997 Jul.

70. Dobutamine stress echocardiography compared with dipyridamole thallium-201 single-photon emission computed tomography in detecting coronary artery disease.

Ho FM; Huang PJ; Liau CS; Lee FK; Chieng PU; Su CT; Lee YT.
European Heart Journal. 16(4):570-5, 1995 Apr.

71. Diagnosis of coronary artery disease using dipyridamole thallium-201 imaging.

Chao CL; Lee YT; Chieng PU; Ho FM; Shiau YC; Shen SJ; Su CT; Huang PJ.
Journal of the Formosan Medical Association. 93(11-12):906-10, 1994 Nov-Dec.

72. Detection of transmural myocardial infarction by single-photon emission computed tomography with thallium-201: comparison with planar imaging.

Ho FM; Han ML; Lo HM; Huang PJ.
Taiwan i Hsueh Hui Tsa Chih - Journal of the Formosan Medical Association. 88(11-12):1104-8, 1989 Nov-Dec.
 

老化醫學Aging